Interleukin 8 Receptor Beta / IL8RB (CXCR2) Antibody
312€ (50 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Interleukin 8 Receptor Beta / IL8RB (CXCR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx270172
tested applications
FCM
Description
Interleukin 8 Receptor Beta (IL8Rb) Antibody is a Rabbit Polyclonal Antibody against Interleukin 8 Receptor Beta (IL8Rb) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 8 Receptor Beta / IL8RB (CXCR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 50 tests |
| Size 2 | 100 tests |
| Size 3 | 200 tests |
| Size 4 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CXCR2,C-X-C motif chemokine receptor 2,CD182,IL8R2,IL8RA,IL8RB,CMKAR2,WHIMS2,CDw128b,KC receptor,CXC-R2,high affinity interleukin-8 receptor B,CD128,Gpcr16 |
| Background | Antibody anti-CXCR2 |
| Status | RUO |
Descripción
CXCR2 is a G protein-coupled receptor that binds IL-8 and other CXC chemokines like Groα, Groβ, and NAP-2. It is mainly expressed on neutrophils, endothelial cells, and monocytes, mediating chemotaxis, neutrophil activation, and cytokine release during inflammation. CXCR2 signaling activates pathways such as PI3K, MAPK, and NF-κB, while its rapid desensitization and internalization regulate signal duration. CXCR2 is critical for immune surveillance and inflammation but also contributes to diseases like COPD, asthma, and rheumatoid arthritis due to excessive neutrophil infiltration. In cancer, CXCR2 promotes tumor progression, angiogenesis, and metastasis by recruiting myeloid-derived suppressor cells (MDSCs) and endothelial cells to the tumor microenvironment, enhancing immunosuppression and vascularization. CXCR2 inhibition reduces tumor growth and inflammation, highlighting its therapeutic potential. It also regulates leukocyte trafficking and tissue repair but contributes to pathologies like cystic fibrosis and inflammatory bowel disease (IBD) when dysregulated. Overall, CXCR2 is key for immune cell recruitment and inflammation, balancing host defense with disease progression.
Related Products
Human CXCR2(C-X-C chemokine receptor type 2) ELISA Kit
Ver Producto
Mouse CXCR2(C-X-C chemokine receptor type 2) ELISA Kit
Ver Producto