Interleukin 21 (IL21) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Interleukin 21 (IL21) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx005462
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
IL21 Antibody is a Rabbit Polyclonal antibody against IL21. This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 21 (IL21) Immunogen: Recombinant protein corresponding to IL21. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/100 - 1/500, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 19 kDa Observed MW: 19 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HBE4 |
| Gene ID | 59067 |
| NCBI Accession | NP_068575.1 |
| Alias | Za11,IL-21,CVID11 |
| Background | Antibody anti-IL21 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interleukin 21 (IL21) is a potent cytokine produced primarily by activated CD4+ T cells, particularly T follicular helper (Tfh) cells and T helper 17 (Th17) cells. It belongs to the type I cytokine family and plays a critical role in regulating both innate and adaptive immune responses. IL-21 acts on a variety of immune cells, including B cells, T cells, natural killer (NK) cells, and dendritic cells (DCs), modulating their proliferation, differentiation, and functional activities. Its broad immunomodulatory effects make it a key regulator of immune homeostasis, inflammation, and host defense against pathogens and tumors. IL-21 is crucial for the development of germinal centers and the production of high-affinity antibodies, particularly through its regulation of B cell differentiation and antibody class switching. It also plays a significant role in promoting the cytotoxic activity of NK cells and CD8+ T cells, which are essential for anti-tumor and antiviral immunity
Productos relacionados
Interleukin 21 (IL21) Antibody
IL21 Antibody is a Rabbit Polyclonal antibody against IL21. This gene encodes a member of the common-gamma chain family …
Ver producto
Interleukin 21 (IL21) Antibody
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the pr…
Ver producto
Low Sample Volume Human Interleukin 21 (IL21) ELISA Kit
Low Sample Volume Human Interleukin 21 (IL21) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Hum…
Ver producto