Interleukin 2 Receptor Beta (IL2RB) Antibody
221€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Interleukin 2 Receptor Beta (IL2RB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx328054
tested applications
ELISA, WB, IF/ICC
Description
IL2RB Antibody is a Rabbit Polyclonal against IL2RB.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 2 Receptor Beta (IL2RB) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14784 |
| Gene ID | 3560 |
| Alias | CD122,IMD63,IL15RB,P70-75,High affinity IL-2 receptor subunit beta,Interleukin-15 receptor subunit beta |
| Background | Antibody anti-IL2RB |
| Status | RUO |
Descripción
IL2RB, or interleukin-2 receptor beta subunit, is a crucial component of the interleukin-2 (IL-2) receptor complex. The IL-2 receptor is vital for T cell activation, proliferation, and survival and is central to immune responses. IL2RB, specifically, is essential for transmitting signals that control the growth, differentiation, and survival of T cells. The IL-2 receptor complex consists of three subunits: the IL-2 receptor alpha (IL2RA or CD25), IL-2 receptor beta (IL2RB or CD122), and IL-2 receptor gamma (IL2RG or CD132). Together, these subunits form a high-affinity receptor for IL-2 that is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cell types. IL2RB, encoded by the IL2RB gene on chromosome 22q12.3, is a key signaling subunit. It binds IL-2 with intermediate affinity independently but, when combined with IL2RG, forms the high-affinity IL-2 receptor that effectively transmits intracellular signals upon IL-2 binding. IL2RB plays a significant role in immune homeostasis and regulation, influencing T cell differentiation, NK cell development, and peripheral tolerance. Dysregulation of IL2RB expression or function is linked to various immune disorders, including autoimmune diseases, immunodeficiencies, and certain cancers.
Related Products
Human Interleukin 2 Receptor Beta (IL2RB) CLIA Kit
Human Interleukin 2 Receptor Beta (IL-2Rb) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Interleukin 2 Receptor Beta (IL-2Rb).
Ver Producto
IL2RB (pY364) Antibody
IL2RB (pY364) Antibody is a Rabbit Polyclonal against IL2RB (pY364).
Ver Producto
Mouse Interleukin 2 Receptor Beta (IL2RB) ELISA Kit
Mouse Interleukin 2 Receptor Beta (IL2RB) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Interleukin 2 Receptor Beta (IL2RB) concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto