IL2RB (pY364) Antibody
429€ (100 µl)
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935106861
info@markelab.com
name
IL2RB (pY364) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx333049
tested applications
ELISA, WB
Description
IL2RB (pY364) Antibody is a Rabbit Polyclonal against IL2RB (pY364).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | IL2RB (pY364) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14784 |
| Alias | CD122,IMD63,IL15RB,P70-75,High affinity IL-2 receptor subunit beta,Interleukin-15 receptor subunit beta |
| Background | Antibody anti-IL2RB |
| Status | RUO |
Descripción
IL2RB, or interleukin-2 receptor beta subunit, is a crucial component of the interleukin-2 (IL-2) receptor complex. The IL-2 receptor is vital for T cell activation, proliferation, and survival and is central to immune responses. IL2RB, specifically, is essential for transmitting signals that control the growth, differentiation, and survival of T cells. The IL-2 receptor complex consists of three subunits: the IL-2 receptor alpha (IL2RA or CD25), IL-2 receptor beta (IL2RB or CD122), and IL-2 receptor gamma (IL2RG or CD132). Together, these subunits form a high-affinity receptor for IL-2 that is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cell types. IL2RB, encoded by the IL2RB gene on chromosome 22q12.3, is a key signaling subunit. It binds IL-2 with intermediate affinity independently but, when combined with IL2RG, forms the high-affinity IL-2 receptor that effectively transmits intracellular signals upon IL-2 binding. IL2RB plays a significant role in immune homeostasis and regulation, influencing T cell differentiation, NK cell development, and peripheral tolerance. Dysregulation of IL2RB expression or function is linked to various immune disorders, including autoimmune diseases, immunodeficiencies, and certain cancers.
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