Interleukin 12 Receptor Subunit Beta-1 (IL12RB1) Antibody
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Description
Interleukin 12 Receptor Subunit Beta-1 (IL12RB1) Antibody is a Rabbit polyclonal antibody for the detection of Human Interleukin 12 Receptor Subunit Beta-1 (IL12RB1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 12 Receptor Subunit Beta-1 (IL12RB1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to 2 weeks. For long-term storage, aliquot and store at -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42701 |
| Gene ID | 3594 |
| NCBI Accession | NP_001276952.1 |
| Alias | IL-12 receptor subunit beta-1,CD212,IMD30,IL12RB,IL-12R-BETA1,IL-12 receptor beta component |
| Background | Antibody anti-IL12RB1 |
| Status | RUO |
Descripción
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anti- IL12RB1 antibody
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
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Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody
IL12RB1 Antibody is a Rabbit Polyclonal antibody against IL12RB1. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
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