Human Interleukin 12 Receptor Beta 1 (IL12Rb1) Protein
2626€ (1 mg)
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name
Human Interleukin 12 Receptor Beta 1 (IL12Rb1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067434
tested applications
WB, SDS-PAGE
Description
Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 12 Receptor Beta 1 (IL12Rb1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 23.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro37-Glu234 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42701 |
| Alias | IL-12 receptor subunit beta-1,CD212,IMD30,IL12RB,IL-12R-BETA1,IL-12 receptor beta component |
| Background | Protein IL12RB1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interleukin 12 receptor subunit beta 1 (IL12RB1) is a protein that serves as an integral component of the interleukin-12 receptor (IL-12R) complex, a receptor system critical for immune function. IL12RB1 is encoded by the IL12RB1 gene and is highly expressed in immune cells, primarily on T cells, natural killer (NK) cells, and macrophages. It plays a central role in mediating immune responses, specifically by binding to the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23), which are essential for driving Th1-type immune responses and promoting cell-mediated immunity. Through this role, IL12RB1 is key in defending the body against intracellular pathogens such as Mycobacterium tuberculosis and certain viruses. The IL-12R complex comprises two main subunits: IL12RB1 and IL12RB2. IL12RB1 forms a binding receptor for both IL-12 and IL-23, and its expression level and function are vital for proper immune function. Genetic mutations in IL12RB1 are linked to immunodeficiency syndromes, as individuals with these mutations have impaired responses to IL-12 and IL-23, resulting in compromised resistance to infections. The receptor’s functionality is therefore critical for immune cell activation, proliferation, and differentiation, particularly within the adaptive immune response.
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