Human Interleukin 12 Receptor Beta 1 (IL12Rb1) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Recombinant Interleukin 12 Receptor Beta 1 (IL12Rb1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 12 Receptor Beta 1 (IL12Rb1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 23.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro37-Glu234 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42701 |
| Alias | IL-12 receptor subunit beta-1,CD212,IMD30,IL12RB,IL-12R-BETA1,IL-12 receptor beta component |
| Background | Protein IL12RB1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interleukin 12 receptor subunit beta 1 (IL12RB1) is a protein that serves as an integral component of the interleukin-12 receptor (IL-12R) complex, a receptor system critical for immune function. IL12RB1 is encoded by the IL12RB1 gene and is highly expressed in immune cells, primarily on T cells, natural killer (NK) cells, and macrophages. It plays a central role in mediating immune responses, specifically by binding to the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23), which are essential for driving Th1-type immune responses and promoting cell-mediated immunity. Through this role, IL12RB1 is key in defending the body against intracellular pathogens such as Mycobacterium tuberculosis and certain viruses. The IL-12R complex comprises two main subunits: IL12RB1 and IL12RB2. IL12RB1 forms a binding receptor for both IL-12 and IL-23, and its expression level and function are vital for proper immune function. Genetic mutations in IL12RB1 are linked to immunodeficiency syndromes, as individuals with these mutations have impaired responses to IL-12 and IL-23, resulting in compromised resistance to infections. The receptor’s functionality is therefore critical for immune cell activation, proliferation, and differentiation, particularly within the adaptive immune response.
Related Products
Human IL-12RB1(Interleukin-12 receptor subunit beta-1 78) ELISA Kit
Ver Producto
anti- IL12RB1 antibody
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Ver Producto
Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody
IL12RB1 Antibody is a Rabbit Polyclonal antibody against IL12RB1. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
Ver Producto