Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody
637€ (100 µl)
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Name
Interleukin 12 Receptor Beta 1 (IL12RB1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx113235
Tested Applications
ELISA, WB
Description
Interleukin 12 Receptor, Beta 1 Antibody is a Rabbit Polyclonal antibody against Interleukin 12 Receptor, Beta 1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 12 Receptor Beta 1 (IL12RB1) Immunogen: Human IL12RB1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42701 |
| Gene ID | 3594 |
| NCBI Accession | NP_001276952.1, NM_001290023.1, NP_005526.1, NM_005535.2 |
| OMIM | 601604 |
| Alias | IL-12 receptor subunit beta-1,CD212,IMD30,IL12RB,IL-12R-BETA1,IL-12 receptor beta component |
| Background | Antibody anti-IL12RB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interleukin 12 receptor subunit beta 1 (IL12RB1) is a protein that serves as an integral component of the interleukin-12 receptor (IL-12R) complex, a receptor system critical for immune function. IL12RB1 is encoded by the IL12RB1 gene and is highly expressed in immune cells, primarily on T cells, natural killer (NK) cells, and macrophages. It plays a central role in mediating immune responses, specifically by binding to the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23), which are essential for driving Th1-type immune responses and promoting cell-mediated immunity. Through this role, IL12RB1 is key in defending the body against intracellular pathogens such as Mycobacterium tuberculosis and certain viruses. The IL-12R complex comprises two main subunits: IL12RB1 and IL12RB2. IL12RB1 forms a binding receptor for both IL-12 and IL-23, and its expression level and function are vital for proper immune function. Genetic mutations in IL12RB1 are linked to immunodeficiency syndromes, as individuals with these mutations have impaired responses to IL-12 and IL-23, resulting in compromised resistance to infections. The receptor’s functionality is therefore critical for immune cell activation, proliferation, and differentiation, particularly within the adaptive immune response.
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