Interleukin 10 Receptor Beta (IL10RB) Antibody (FITC)
169€ (20 µg)
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Name
Interleukin 10 Receptor Beta (IL10RB) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx336157
Description
IL10RB Antibody (FITC) is a Rabbit Polyclonal against IL10RB.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 10 Receptor Beta (IL10RB) Immunogen: Recombinant Human Interleukin-10 receptor subunit beta protein (79-219AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Assay Type | Concentration: 0.25 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q08334 |
| Gene ID | 3588 |
| Alias | CRFB4,Cytokine receptor family 2 member 4,CRF2-4,Interleukin-10 receptor subunit 2,IL-10R subunit 2,IL-10R2 |
| Background | Antibody anti-IL10RB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL10RB is a shared receptor subunit within the IL10 receptor complex that interacts with IL10RA to propagate IL10 signaling It is widely expressed across immune and non-immune cell types, highlighting its role in diverse biological processes beyond IL10 signaling IL10RB forms a functional receptor complex with IL10RA and is also involved in the signaling pathways of cytokines such as IL22, IL26, and type III interferons (IFN-λ) Upon binding IL10, IL10RB recruits TYK2 kinase, facilitating activation of the JAK1/STAT3 signaling cascade to suppress pro-inflammatory cytokines and regulate immune tolerance Mutations in IL10RB lead to disrupted IL10 signaling and are strongly linked to severe early-onset IBD, systemic inflammation, and immune dysregulation IL10RB’s shared use in other cytokine pathways highlights its broad immunoregulatory function, making it crucial in the resolution of inflammation and antiviral immune responses Dysregulation of IL10RB has been associated with chronic inflammatory disorders, autoimmunity, and heightened susceptibility to viral infections Therapeutic approaches aimed at modulating IL10RB activity are being explored for managing inflammatory and infectious diseases, as enhancing IL10RB signaling can reestablish immune balance and prevent tissue damage caused by excessive inflammation
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