Interleukin 10 (IL10) Antibody (HRP)
169€ (20 µg)
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935106861
info@markelab.com
name
Interleukin 10 (IL10) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx109076
tested applications
ELISA
Description
Interleukin-10 Antibody (HRP) is a Rabbit Polyclonal antibody against Interleukin-10 conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 10 (IL10) |
| Host | Rabbit |
| Reactivity | Cow |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43480 |
| Gene ID | 281246 |
| Alias | CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor |
| Background | Antibody anti-IL10 |
| Status | RUO |
Descripción
IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections
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