Interleukin 10 (IL10) Antibody (APC)
117€ (20 tests)
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935106861
info@markelab.com
name
Interleukin 10 (IL10) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx229440
tested applications
FCM
Description
IL-10 Antibody (APC) is a Human Monoclonal Antibody against IL-10.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 10 (IL10) |
| Host | Rat |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG1 Kappa |
| Size 1 | 20 tests |
| Size 2 | 100 tests |
| Size 3 | 200 tests |
| Tested Applications | FCM |
| Buffer | PBS with 0.05% Proclin300, 1% BSA. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P22301 |
| Gene ID | 3586 |
| Alias | CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor |
| Background | Antibody anti-IL10 |
| Status | RUO |
Descripción
IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections
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