Interleukin-1 Receptor-Like 1 (IL1RL1) Antibody (Capture Ab)

Este producto es parte de IL1RL1 - Interleukin 1 Receptor Like Protein 1
Interleukin-1 Receptor-Like 1 (IL1RL1) Antibody (Capture Ab)

Pida mas información

935106861

info@markelab.com

Precio

618.75€ (1 mg)

Antibody anti-IL1RL1

proveedor

Abbexa

reference

abx019310

Tested Applications

ELISA, CLIA

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

Interleukin-1 Receptor-Like 1 (IL1RL1) Antibody (Capture Ab) is a Mouse Monoclonal antibody against IL1RL1/ST2. For sandwich immunoassays, it is recommended to use abx019310 (this product) as the capture antibody and abx019311 as the detection antibody.


Background

IL1RL1, also known as ST2, is a member of the IL-1 receptor family that serves as the receptor for interleukin-33 (IL-33), a cytokine involved in type 2 immune responses, tissue repair, and inflammation. IL1RL1 exists in both membrane-bound and soluble isoforms, where the membrane-bound form (ST2L) mediates IL-33 signaling, while the soluble form (sST2) acts as a decoy receptor to neutralize IL-33 activity. Upon IL-33 binding, IL1RL1 forms a heterodimeric complex with IL1RAP, leading to the activation of NF-κB, ERK, and p38 MAPK signaling pathways, which promote cytokine production and immune cell activation. IL1RL1 is highly expressed on Th2 cells, mast cells, eosinophils, and innate lymphoid cells, where it regulates allergic inflammation, tissue homeostasis, and host defense. Dysregulation of IL1RL1 is implicated in allergic asthma, atopic dermatitis, cardiovascular diseases, and fibrotic disorders, where excessive IL-33 signaling drives pathological inflammation and tissue remodeling. Functional studies show that loss of IL1RL1 results in impaired type 2 immune responses, reduced cytokine production, and defective tissue repair, emphasizing its role in immune regulation, inflammation, and tissue homeostasis.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Interleukin-1 Receptor-Like 1 (IL1RL1)


host

Mouse


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, CLIA


purity

> 95% (HPLC and SDS-PAGE)


purification

Purified by Protein A or Protein G.


buffer

0.9% NaCl without preservative.


size 1

1 mg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

IL1RL1


dry ice

No


availability

Shipped within 5-10 working days.


alias

IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V


note

This product is for research use only.


Quizá le pueda interesar

Human IL1RL1(Interleukin-1 receptor-like 1) ELISA Kit

Human IL1RL1(Interleukin-1 receptor-like 1) ELISA Kit

proveedor

FineTest

reference

EH0188

reactivity

human

status

RUO

Precio a consultar

Ver más

Rat IL1RL1(IL-1 Receptor Like 1) ELISA Kit

Rat IL1RL1(IL-1 Receptor Like 1) ELISA Kit

proveedor

FineTest

reference

ER1567

reactivity

rat

status

RUO

Precio a consultar

Ver más

Interleukin 1 Receptor Like Protein 1 (IL1RL1) Antibody

Interleukin 1 Receptor Like Protein 1 (IL1RL1) Antibody

proveedor

Abbexa

reference

abx019114

Tested Applications

WB

reactivity

Mouse

status

RUO

clonality

Polyclonal

IL1RL1 Antibody is a Rabbit Polyclonal antibody against Mouse.

300€ (100 µg)

Ver más