Interleukin 1 Receptor Antagonist (IL1RN) Antibody
507€ (500 µg)
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Name
Interleukin 1 Receptor Antagonist (IL1RN) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137017
Description
Interleukin 1 Receptor Antagonist (IL1RN) Antibody is a Mouse Monoclonal antibody against Interleukin 1 Receptor Antagonist (IL1RN).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 1 Receptor Antagonist (IL1RN) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Size 1 | 500 µg |
| Size 2 | 1 mg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P18510 |
| Gene ID | 3557 |
| OMIM | 147679 |
| Alias | IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor |
| Background | Antibody anti-IL1RN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression
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