Interferon Type A1/A2 (IFNA1) Antibody
292.5€ (80 µl)
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name
Interferon Type A1/A2 (IFNA1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030045
tested applications
ELISA, WB, FCM
Description
IFNA1 is produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interferon Type A1/A2 (IFNA1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/2000, FCM: 1/25. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01562 |
| Alias | IFL,IFN,IFNA@,IFNA13,leIF D,IFN-ALPHA,IFN-alphaD,IFN-alpha-1/13,Interferon alpha-D |
| Background | Antibody anti-IFNA1 |
| Status | RUO |
Descripción
Interferon Alpha 1 (IFNA1) plays a critical role in the body's innate immune response to viral infections. It is a member of the type I interferon family and is produced by cells such as macrophages, dendritic cells, and lymphocytes in response to pathogenic challenges, including viral RNA or DNA. IFNA1 binds to the interferon-alpha/beta receptor (IFNAR) on target cells, triggering a signaling cascade that activates the JAK-STAT pathway. This leads to the transcription of numerous interferon-stimulated genes, enhancing antiviral defense mechanisms by inhibiting viral replication, promoting apoptosis of infected cells, and activating immune cells like NK cells and cytotoxic T lymphocytes. IFNA1 also plays a role in modulating the adaptive immune response by enhancing antigen presentation. Dysregulation of IFNA1 has been implicated in autoimmune conditions such as systemic lupus erythematosus (SLE), and recombinant forms of IFNA1 are used therapeutically for conditions like hepatitis B and C and certain cancers.
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