Interferon Regulatory Factor 4 (IRF4) Antibody
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Description
IRF4 Antibody is a Rabbit Polyclonal antibody against IRF4. Interferon regulatory factor 4 (IRF4) is a member of the IRF family of transcription factors, expressed in most cell types of the immune system. IRF4 is a transcription factor essential for the development of T helper-2 (Th2) cells, IL17-producing Th17 cells, and IL9-producing Th9 cells, as well as dendritic cell (DC). It binds to and activates the interferon-stimulated response element (ISRE) of the MHC class I promoter, and may have a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Interferon Regulatory Factor 4 (IRF4) Immunogen: Recombinant protein corresponding to IRF4. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 52 kDa Observed MW: 55 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15306 |
| Gene ID | 3662 |
| NCBI Accession | NP_002451.2 |
| Background | Antibody anti-IRF4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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IRF4 antibody
Transcriptional activator. Binds to the interferon-stimulated response element(ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence(5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes(By similarity).
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Interferon Regulatory Factor 4 (IRF4) Antibody
IRF4 Antibody is a Rabbit Polyclonal antibody against IRF4. Interferon regulatory factor 4 (IRF4) is a member of the IRF family of transcription factors, expressed in most cell types of the immune system. IRF4 is a transcription factor essential for the development of T helper-2 (Th2) cells, IL17-producing Th17 cells, and IL9-producing Th9 cells, as well as dendritic cell (DC). It binds to and activates the interferon-stimulated response element (ISRE) of the MHC class I promoter, and may have a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
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