Interferon-Induced Protein With Tetratricopeptide Repeats 2 (IFIT2) Antibody
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Description
Interferon-Induced Protein With Tetratricopeptide Repeats 2 (IFIT2) Antibody is a Rabbit polyclonal antibody for the detection of Human Interferon-Induced Protein With Tetratricopeptide Repeats 2 (IFIT2).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interferon-Induced Protein With Tetratricopeptide Repeats 2 (IFIT2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09913 |
| Gene ID | 3433 |
| NCBI Accession | NP_001538.4 |
| Background | Antibody anti-IFIT2 |
| Status | RUO |
Descripción
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IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
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Interferon Induced Protein With Tetratricopeptide Repeats 2 (IFIT2) Antibody
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