Interferon Gamma (IFNG) Antibody
383.5€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Interferon Gamma (IFNG) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx016066
Tested Applications
ELISA
Description
Interferon Gamma (interferon, gamma) is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens.It is a pleiotropic cytokine involved in the regulation of nearly all phases of immune and inflammatory responses, including the activation, growth and differentiation of T cell, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts.The active form of IFN-G is a homodimer with each subunit containing six helices.The dimeric structure of human IFN-G is stabilized by non-covalent interactions through the interface of the helices.IFN-G translated precursor is 166 amino acids, including the 23 amino acid secretory sequence.It is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN.Multiple forms exist due to variable glycosylation and under non-denaturing conditions due to dimers and tetramers.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interferon Gamma (IFNG) Immunogen: Recombinant human IFN-gamma (BioSource company, Cat.No.PHC4033). |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: Not determined. |
| Recommended Dilution | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01579 |
| Gene ID | 3458 |
| OMIM | 147570 |
| Alias | IFG,IFI,IMD69,IFN-gamma,Immune interferon |
| Background | Antibody anti-IFNG |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interferon Gamma (IFNG) is a pivotal cytokine of the immune system, classified as a type II interferon, and is primarily produced by activated T lymphocytes, natural killer (NK) cells, and NKT cells. Unlike type I interferons, IFNG signals through a distinct receptor, the interferon gamma receptor (IFNGR), leading to the activation of the JAK-STAT pathway and the induction of a unique set of genes critical for immune defense. IFNG plays a central role in coordinating both innate and adaptive immune responses, including macrophage activation for enhanced phagocytosis and antigen processing, upregulation of MHC class I and II molecules to improve antigen presentation, and stimulation of cytotoxic T cells. It is also essential in granuloma formation to contain intracellular pathogens, such as Mycobacterium tuberculosis. Dysregulation of IFNG activity is implicated in various inflammatory and autoimmune conditions, as well as chronic infections. Its therapeutic potential in immunotherapy and as a biomarker in certain cancers and infectious diseases remains an active focus of study.
Productos relacionados
Interferon Gamma (IFNG) Antibody
IFNG Antibody is a Rabbit Polyclonal antibody against IFNG. This gene encodes a member of the type II interferon family.…
Ver producto
Interferon Gamma (IFNG) Antibody
Interferon gamma (IFN gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainl…
Ver producto Interferon Gamma (IFNG) Antibody
Interferon Gamma (interferon, gamma) is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natur…
Ver producto