Interferon Beta (IFNb) Antibody

Este producto es parte de IFNB1 - interferon beta 1
Interferon Beta (IFNb) Antibody

Pida mas información

935106861

info@markelab.com

Precio

275€ (100 µl)

Antibody anti-IFNB1

proveedor

Abbexa

reference

abx177036

Tested Applications

WB, IHC, IF/ICC

reactivity

Dog

status

RUO

clonality

Polyclonal

Descripción

Interferon Beta (IFNb) Antibody is a Rabbit Polyclonal antibody against Interferon Beta (IFNb).


Background

Interferon Beta 1 (IFNB1) is a type I interferon with a critical role in antiviral defense and immunoregulation. Produced predominantly by fibroblasts, epithelial cells, and macrophages, IFNB1 is rapidly secreted in response to viral infections and pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors, such as Toll-like receptors (TLRs). Upon secretion, IFNB1 binds to the interferon alpha/beta receptor (IFNAR), triggering the JAK-STAT signaling pathway. This leads to the transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral responses, including the inhibition of viral replication, degradation of viral RNA, and promotion of apoptosis in infected cells. IFNB1 also enhances antigen presentation by upregulating major histocompatibility complex (MHC) class I molecules and bolsters the activation and proliferation of natural killer (NK) cells and cytotoxic T lymphocytes. Clinically, recombinant forms of IFNB1 are widely used in the treatment of multiple sclerosis (MS), where they modulate the inflammatory response and reduce disease progression. Its role in other autoimmune and infectious diseases continues to be an area of active research.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Dog


immunogen target

Interferon Beta (IFNb)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.


buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.


size 1

100 µl


size 2

200 µl


size 3

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

IFNB1


dry ice

No


availability

Shipped within 5-7 working days.


alias

IFB,IFF,IFNB,IFN-beta,IFN-beta 1,Fibroblast interferon 1,IFNB1


note

This product is for research use only.


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