Interferon Beta (IFNb) Antibody
Pida mas información
935106861
info@markelab.com
Precio
275€ (100 µl)
Antibody anti-IFNB1
proveedor
Abbexareference
abx177036Tested Applications
WB, IHC, IF/ICCreactivity
Dogstatus
RUOclonality
PolyclonalDescripción
Interferon Beta (IFNb) Antibody is a Rabbit Polyclonal antibody against Interferon Beta (IFNb).
Background
Interferon Beta 1 (IFNB1) is a type I interferon with a critical role in antiviral defense and immunoregulation. Produced predominantly by fibroblasts, epithelial cells, and macrophages, IFNB1 is rapidly secreted in response to viral infections and pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors, such as Toll-like receptors (TLRs). Upon secretion, IFNB1 binds to the interferon alpha/beta receptor (IFNAR), triggering the JAK-STAT signaling pathway. This leads to the transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral responses, including the inhibition of viral replication, degradation of viral RNA, and promotion of apoptosis in infected cells. IFNB1 also enhances antigen presentation by upregulating major histocompatibility complex (MHC) class I molecules and bolsters the activation and proliferation of natural killer (NK) cells and cytotoxic T lymphocytes. Clinically, recombinant forms of IFNB1 are widely used in the treatment of multiple sclerosis (MS), where they modulate the inflammatory response and reduce disease progression. Its role in other autoimmune and infectious diseases continues to be an area of active research.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Dog
immunogen target
Interferon Beta (IFNb)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
100 µl
size 2
200 µl
size 3
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
IFNB1
dry ice
No
availability
Shipped within 5-7 working days.
alias
IFB,IFF,IFNB,IFN-beta,IFN-beta 1,Fibroblast interferon 1,IFNB1
note
This product is for research use only.
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