Human Interferon Beta 1b (IFNB 1b) Protein
234€ (2 µg)
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Name
Human Interferon Beta 1b (IFNB 1b) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx260713
Tested Applications
SDS-PAGE
Description
Human Interferon Beta 1b (IFNB 1b) Protein is a recombinant cytokine produced in E coli. It consists of a single, non-glycosylated mutein form of Human Interferon-beta 1b polypeptide chain containing 165 AA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interferon Beta 1b (IFNB 1b) |
| Host | E. coli |
| Assay Type | Biological Activity: Specific Activity: 32 × 106 IU/mg. Determined by a viral resistance assay using WISH cells with VSV virus or VERO cells with EMCV virus. Sequence Fragment: 165 AA. |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | 18.51 kDa |
| Expression | Recombinant |
| Purity | > 98% (SDS-PAGE and RP-HPLC) |
| Purification | Purified by proprietary chromatography techniques. Sterile filtered. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 50 mg Human Albumin and 50 mg Mannitol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Storage: Store dessicated below -18°C. After reconstituting store at 4°C for up to a week. Avoid repeated freeze/thaw cycles. Stability: Stable at room temperature for 3 weeks. |
| Dry Ice | No |
| UniProt ID | P01574 |
| Alias | IFB,IFF,IFNB,IFN-beta,IFN-beta 1,Fibroblast interferon 1,IFNB1 |
| Background | Protein IFNB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile 18 MΩ · cm water to a concentration of at least 0.25 µg/ml. This stock solution can be further diluted if required. Concentration: Prior to lyophilization: 1 mg/ml |
Background
Interferon Beta 1 (IFNB1) is a type I interferon with a critical role in antiviral defense and immunoregulation. Produced predominantly by fibroblasts, epithelial cells, and macrophages, IFNB1 is rapidly secreted in response to viral infections and pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors, such as Toll-like receptors (TLRs). Upon secretion, IFNB1 binds to the interferon alpha/beta receptor (IFNAR), triggering the JAK-STAT signaling pathway. This leads to the transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral responses, including the inhibition of viral replication, degradation of viral RNA, and promotion of apoptosis in infected cells. IFNB1 also enhances antigen presentation by upregulating major histocompatibility complex (MHC) class I molecules and bolsters the activation and proliferation of natural killer (NK) cells and cytotoxic T lymphocytes. Clinically, recombinant forms of IFNB1 are widely used in the treatment of multiple sclerosis (MS), where they modulate the inflammatory response and reduce disease progression. Its role in other autoimmune and infectious diseases continues to be an area of active research.
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