Intercellular Adhesion Molecule 3 (ICAM3) Antibody
260€ (100 µl)
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935106861
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name
Intercellular Adhesion Molecule 3 (ICAM3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130863
tested applications
WB, IHC, IF/ICC
Description
Intercellular Adhesion Molecule 3 Antibody is a Rabbit Polyclonal against Intercellular Adhesion Molecule 3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Intercellular Adhesion Molecule 3 (ICAM3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD50,CDW50,ICAM-R,Intercellular adhesion molecule 3 |
| Background | Antibody anti-ICAM3 |
| Status | RUO |
Descripción
Intercellular Adhesion Molecule 3 (ICAM3), also known as CD50, is a member of the immunoglobulin superfamily (IgSF) that plays a crucial role in cell-cell adhesion and immune system regulation. It is expressed predominantly on leukocytes, especially resting lymphocytes, and interacts with integrins to mediate various immune responses, including leukocyte trafficking, T-cell activation, and antigen recognition. ICAM3 is particularly involved in the early stages of immune responses, functioning as a ligand for leukocyte function-associated antigen-1 (LFA-1), an integrin found on T cells and other leukocytes. ICAM-3 acts as a facilitator of immunological synapse formation, helping leukocytes adhere to antigen-presenting cells and promoting signaling pathways critical for immune activation. Its interaction with integrins also promotes adhesion between leukocytes and endothelial cells, an important step in the migration of immune cells to sites of inflammation or infection. ICAM-3 is essential in regulating leukocyte dynamics and activation during immune surveillance and host defense.
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ICAM proteins are ligands for the leukocyte adhesion protein LFA-1(integrin alpha-L/beta-2)(PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages(PubMed:23775590).
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