Human Intercellular Adhesion Molecule 3 (ICAM3) Protein
234€ (10 µg)
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935106861
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name
Human Intercellular Adhesion Molecule 3 (ICAM3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067311
tested applications
WB, SDS-PAGE
Description
Intercellular Adhesion Molecule 3 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Intercellular Adhesion Molecule 3 (ICAM3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly259-Val491 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P32942 |
| Alias | CD50,CDW50,ICAM-R,Intercellular adhesion molecule 3 |
| Background | Protein ICAM3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Intercellular Adhesion Molecule 3 (ICAM3), also known as CD50, is a member of the immunoglobulin superfamily (IgSF) that plays a crucial role in cell-cell adhesion and immune system regulation. It is expressed predominantly on leukocytes, especially resting lymphocytes, and interacts with integrins to mediate various immune responses, including leukocyte trafficking, T-cell activation, and antigen recognition. ICAM3 is particularly involved in the early stages of immune responses, functioning as a ligand for leukocyte function-associated antigen-1 (LFA-1), an integrin found on T cells and other leukocytes. ICAM-3 acts as a facilitator of immunological synapse formation, helping leukocytes adhere to antigen-presenting cells and promoting signaling pathways critical for immune activation. Its interaction with integrins also promotes adhesion between leukocytes and endothelial cells, an important step in the migration of immune cells to sites of inflammation or infection. ICAM-3 is essential in regulating leukocyte dynamics and activation during immune surveillance and host defense.
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ICAM proteins are ligands for the leukocyte adhesion protein LFA-1(integrin alpha-L/beta-2)(PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages(PubMed:23775590).
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