Intercellular Adhesion Molecule 1 (ICAM-1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Intercellular Adhesion Molecule 1 (ICAM-1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234103
tested applications
ELISA, WB, IHC, FCM
Description
ICAM-1 Antibody is a Mouse Monoclonal against ICAM-1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Intercellular Adhesion Molecule 1 (ICAM-1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/4000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05362 |
| Gene ID | 3383 |
| OMIM | 147840 |
| Alias | BB2,CD54,P3.58,ICAM-1 |
| Background | Antibody anti-ICAM1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Intercellular Adhesion Molecule 1 (ICAM-1) is a protein encoded by the ICAM1 gene in humans. It plays a crucial role in the immune response by aiding in the adhesion of leukocytes to the endothelial cells lining blood vessels. ICAM-1. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium. ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the protein. ICAM-1 is important for the process of leukocyte extravasation, which is how white blood cells move from the bloodstream to infected or injured tissues. It helps leukocytes stick to endothelial cells, a crucial step in the inflammatory response. ICAM-1 can also trigger intracellular signaling events when it binds to its ligands, influencing cellular processes related to inflammation and immune responses.
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