Integrin Beta-1 (ITGB1) Antibody (AF488)

Este producto es parte de ITGB1 - integrin subunit beta 1
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117€ (20 tests)

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935106861
info@markelab.com
name
Integrin Beta-1 (ITGB1) Antibody (AF488)
category
Primary Antibodies
provider
Abbexa
reference
abx228479
tested applications
FCM

Description

CD29 Antibody (AF488) is a Human Monoclonal Antibody against CD29.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Integrin Beta-1 (ITGB1)
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Conjugation
AF488
Isotype
IgG1
Size 1
20 tests
Size 2
100 tests
Size 3
200 tests
Tested Applications
FCM
Buffer
PBS with 0.05% Proclin300, 1% BSA.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P05556
Gene ID
3688
Alias
CD29,FNRB,MDF2,VLAB,GPIIA,MSK12,VLA-BETA,Integrin beta-1,Fibronectin receptor subunit beta,Glycoprotein Iia,VLA-4 subunit beta
Background
Antibody anti-ITGB1
Status
RUO

Descripción

ITGB1, also known as integrin subunit beta 1 or CD29, is a crucial component of integrins, a large family of cell adhesion molecules involved in mediating interactions between cells and the extracellular matrix (ECM). Integrins play a vital role in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. ITGB1, in particular, is an essential β subunit that pairs with multiple α subunits to form a variety of heterodimeric integrins. These integrins facilitate the binding of cells to ECM proteins, such as fibronectin, collagen, and laminin, and are critical for tissue integrity, wound healing, and development. ITGB1 is ubiquitously expressed across many cell types and tissues, including fibroblasts, endothelial cells, epithelial cells, and immune cells, reflecting its broad role in cellular homeostasis and signaling. Its function extends beyond simple adhesion, as ITGB1 integrins are involved in transmitting signals bidirectionally across the cell membrane, influencing cellular behavior based on external cues. Through a process called "outside-in" and "inside-out" signaling, ITGB1 integrins regulate cell motility, polarity, and survival, contributing to embryogenesis, immune responses, and cancer progression.

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