Integrin Beta 1 (ITGB1) Antibody

292.5€ (80 µl)
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name
Integrin Beta 1 (ITGB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034994
tested applications
ELISA, WB
Description
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Integrin Beta 1 (ITGB1) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | IgG1 |
Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
Size 1 | 80 µl |
Size 2 | 400 µl |
Form | Liquid |
Tested Applications | ELISA, WB |
Buffer | PBS containing 0.09% sodium azide. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P05556 |
NCBI Accession | NP_002202.2, NP_391988.1, NP_596867.1 |
Alias | CD29,FNRB,MDF2,VLAB,GPIIA,MSK12,VLA-BETA,Integrin beta-1,Fibronectin receptor subunit beta,Glycoprotein Iia,VLA-4 subunit beta |
Background | Antibody anti-ITGB1 |
Status | RUO |
Descripción
ITGB1, also known as integrin subunit beta 1 or CD29, is a crucial component of integrins, a large family of cell adhesion molecules involved in mediating interactions between cells and the extracellular matrix (ECM). Integrins play a vital role in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. ITGB1, in particular, is an essential β subunit that pairs with multiple α subunits to form a variety of heterodimeric integrins. These integrins facilitate the binding of cells to ECM proteins, such as fibronectin, collagen, and laminin, and are critical for tissue integrity, wound healing, and development. ITGB1 is ubiquitously expressed across many cell types and tissues, including fibroblasts, endothelial cells, epithelial cells, and immune cells, reflecting its broad role in cellular homeostasis and signaling. Its function extends beyond simple adhesion, as ITGB1 integrins are involved in transmitting signals bidirectionally across the cell membrane, influencing cellular behavior based on external cues. Through a process called "outside-in" and "inside-out" signaling, ITGB1 integrins regulate cell motility, polarity, and survival, contributing to embryogenesis, immune responses, and cancer progression.
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