Integrin Beta 1 (ITGB1) Antibody
637€ (100 µl)
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name
Integrin Beta 1 (ITGB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx113190
tested applications
ELISA, WB
Description
Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen Cd29 Includes Mdf2, Msk12) Antibody is a Rabbit Polyclonal antibody against Integrin, Beta 1 (Fibronectin Receptor, Beta Polypeptide, Antigen Cd29 Includes Mdf2, Msk12).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Beta 1 (ITGB1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05556 |
| Gene ID | 3688 |
| NCBI Accession | NP_002202.2, NM_002211.3 |
| OMIM | 135630 |
| Alias | CD29,FNRB,MDF2,VLAB,GPIIA,MSK12,VLA-BETA,Integrin beta-1,Fibronectin receptor subunit beta,Glycoprotein Iia,VLA-4 subunit beta |
| Background | Antibody anti-ITGB1 |
| Status | RUO |
Descripción
ITGB1, also known as integrin subunit beta 1 or CD29, is a crucial component of integrins, a large family of cell adhesion molecules involved in mediating interactions between cells and the extracellular matrix (ECM). Integrins play a vital role in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. ITGB1, in particular, is an essential β subunit that pairs with multiple α subunits to form a variety of heterodimeric integrins. These integrins facilitate the binding of cells to ECM proteins, such as fibronectin, collagen, and laminin, and are critical for tissue integrity, wound healing, and development. ITGB1 is ubiquitously expressed across many cell types and tissues, including fibroblasts, endothelial cells, epithelial cells, and immune cells, reflecting its broad role in cellular homeostasis and signaling. Its function extends beyond simple adhesion, as ITGB1 integrins are involved in transmitting signals bidirectionally across the cell membrane, influencing cellular behavior based on external cues. Through a process called "outside-in" and "inside-out" signaling, ITGB1 integrins regulate cell motility, polarity, and survival, contributing to embryogenesis, immune responses, and cancer progression.
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