Integrin Alpha M / CD11b (ITGAM) Antibody Pair
Pida mas información
935106861
info@markelab.com
Precio
1118€ (5 × 96 tests)
Antibody Pair for ITGAM
proveedor
Abbexareference
abx370883Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Integrin Alpha M / CD11b (ITGAM) Antibody Pair for use in Sandwich ELISA assay development.
Background
Integrin Subunit Alpha M (ITGAM), also known as CD11b, is a transmembrane glycoprotein expressed predominantly on the surface of monocytes, macrophages, granulocytes, and some dendritic cells. ITGAM forms a heterodimer with integrin beta-2 (ITGB2) to create the Mac-1 complex, which is crucial in mediating adhesion and migration of leukocytes during inflammatory and immune responses. The protein plays a pivotal role in immune surveillance and host defense by facilitating phagocytosis, complement receptor activity, and migration across endothelial barriers. Additionally, ITGAM is involved in the recognition and clearance of pathogens and apoptotic cells. Aberrations in ITGAM expression or mutations have been linked to systemic lupus erythematosus (SLE) and other autoimmune disorders. It is also a key player in immune evasion mechanisms employed by certain pathogens.
Características del producto
category
Antibody Pairs
reactivity
Human
immunogen target
Integrin Alpha M / CD11b (ITGAM)
form
Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. The recommended reconstitution volume is 1.0 ml for a standard curve range of 0.78 ng/ml - 50 ng/ml.
tested applications
ELISA
size 1
5 × 96 tests
size 2
10 × 96 tests
recommended dilution
Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user.
buffer
The Capture and Detection Antibody both contain 0.1% sodium azide.
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ITGAM
dry ice
No
availability
Shipped within 5-20 working days.
alias
CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor
uniprot id
note
This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only.
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