Integrin Alpha-E / CD103 (ITGAE) Antibody
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Description
ITGAE Antibody is a Rabbit Polyclonal against ITGAE.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Alpha-E / CD103 (ITGAE) Immunogen: Fusion protein of human ITGAE. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P38570 |
| Gene ID | 3682 |
| Alias | CD103,HUMINAE,Integrin alpha-E,HML-1 antigen,Integrin alpha-IEL,Mucosal lymphocyte 1 antigen |
| Background | Antibody anti-ITGAE |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Integrin subunit alpha E, known as ITGAE, is a critical component of the immune system, particularly in regulating immune cell retention in epithelial tissues. ITGAE, often referred to as CD103 in immunological contexts, partners with the integrin beta 7 subunit to form the heterodimeric receptor αEβ7. This integrin is specifically expressed on subsets of immune cells, including mucosal T lymphocytes, dendritic cells, and natural killer (NK) cells, where it binds to E-cadherin, an adhesion molecule on epithelial cells. By binding E-cadherin, αEβ7 plays a critical role in localizing lymphocytes to epithelial tissues, particularly within the gut, skin, and lungs, where immune surveillance is essential. This adhesion mechanism enables αEβ7-expressing cells to provide targeted immune responses and maintain tissue integrity.
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