Integrin Alpha 6 (ITGA6) Antibody (FITC)
468€ (100 µg)
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Name
Integrin Alpha 6 (ITGA6) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx413622
Tested Applications
FCM
Description
Integrin Alpha 6 (ITGA6) Antibody (FITC) is a Mouse Monoclonal antibody against CD49f.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Alpha 6 (ITGA6) |
| Host | Mouse |
| Reactivity | Rat |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Assay Type | Concentration: 0.1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | FITC |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | PBS, 1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | JEB6,CD49f,VLA-6,ITGA6A,ITGA6B,Integrin alpha-6,CD49 antigen-like family member F |
| Background | Antibody anti-ITGA6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Integrin subunit alpha 6 (ITGA6) is part of the integrin family, a group of transmembrane receptors that mediate cell adhesion and interactions with the extracellular matrix (ECM). ITGA6 specifically pairs with either integrin beta 1 (ITGB1) or integrin beta 4 (ITGB4) to form the α6β1 and α6β4 integrins, which primarily bind to laminins, an essential component of the basement membrane. These integrin complexes play critical roles in tissue integrity, cellular architecture, and signal transduction, mediating functions such as cell adhesion, migration, proliferation, and differentiation. In pathological conditions, dysregulation of ITGA6 has been implicated in cancer progression, tissue fibrosis, and inflammatory diseases. Due to its involvement in cancer cell migration and invasion, ITGA6 is considered a potential therapeutic target, particularly in cancers of epithelial origin.
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