Integrin Alpha 6 (ITGA6) Antibody
292.5€ (80 µl)
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Name
Integrin Alpha 6 (ITGA6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx031688
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Alpha 6 (ITGA6) Immunogen: KLH-conjugated synthetic peptide between 1043-1072 amino acids from human ITGA6. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23229 |
| NCBI Accession | NP_000201.2, NP_001073286.1 |
| Alias | JEB6,CD49f,VLA-6,ITGA6A,ITGA6B,Integrin alpha-6,CD49 antigen-like family member F |
| Background | Antibody anti-ITGA6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Integrin subunit alpha 6 (ITGA6) is part of the integrin family, a group of transmembrane receptors that mediate cell adhesion and interactions with the extracellular matrix (ECM). ITGA6 specifically pairs with either integrin beta 1 (ITGB1) or integrin beta 4 (ITGB4) to form the α6β1 and α6β4 integrins, which primarily bind to laminins, an essential component of the basement membrane. These integrin complexes play critical roles in tissue integrity, cellular architecture, and signal transduction, mediating functions such as cell adhesion, migration, proliferation, and differentiation. In pathological conditions, dysregulation of ITGA6 has been implicated in cancer progression, tissue fibrosis, and inflammatory diseases. Due to its involvement in cancer cell migration and invasion, ITGA6 is considered a potential therapeutic target, particularly in cancers of epithelial origin.
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