Integrin Alpha-5 (ITGA5) Antibody
286€ (50 µg)
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name
Integrin Alpha-5 (ITGA5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx421389
tested applications
FCM
Description
Integrin Alpha-5 (ITGA5) Antibody is a Human Monoclonal antibody for the detection of Integrin Alpha-5 (ITGA5) in Human samples.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Alpha-5 (ITGA5) |
| Host | Human |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG4 |
| Clone ID | V186 |
| Purity | > 95% |
| Purification | Purified by Protein A/G affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08648 |
| Gene ID | 3678 |
| NCBI Accession | NP_002196.4 |
| Alias | FNRA,CD49e,VLA-5,VLA5A,Integrin alpha-5,Integrin alpha-5,Fibronectin receptor subunit alpha,Integrin alpha-F |
| Background | Antibody anti-ITGA5 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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ITGA5 antibody
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site(site 2) which is distinct from the classical ligand-binding site(site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1(PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1(FBN1) and mediates R-G-D-dependent cell adhesion to FBN1(PubMed:12807887, PubMed:17158881).
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