Integrator Complex Subunit 3 (INTS3) Antibody
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Description
Integrator Complex Subunit 3 Antibody is a Rabbit Polyclonal antibody against Integrator Complex Subunit 3.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrator Complex Subunit 3 (INTS3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q68E01 |
| Gene ID | 65123 |
| NCBI Accession | NP_001311404.1, NM_001324475.1 |
| OMIM | 611347 |
| Background | Antibody anti-INTS3 |
| Status | RUO |
Descripción
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Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs(snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain(CTD) of RNA polymerase II largest subunit(POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks(DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
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Integrator Complex Subunit 3 (INTS3) Antibody
Integrator Complex Subunit 3 Antibody is a Rabbit Polyclonal antibody against Integrator Complex Subunit 3.
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