Insulin Receptor Substrate 4 (IRS4) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Insulin Receptor Substrate 4 (IRS4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131525
tested applications
WB, IHC, IF/ICC
Description
Insulin Receptor Substrate 4 Antibody is a Rabbit Polyclonal against Insulin Receptor Substrate 4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Receptor Substrate 4 (IRS4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14654 |
| Alias | IRS-4,160 kDa phosphotyrosine protein,CHNG9, PY160 |
| Background | Antibody anti-IRS4 |
| Status | RUO |
| Note | Concentration: 0.42 mg/ml - |
Descripción
Insulin receptor substrate 4 (IRS4) is another member of the IRS protein family, contributing to insulin and growth factor-mediated signal transduction. Unlike other IRS proteins, IRS4 displays a more tissue-specific expression pattern, being predominantly found in the brain, liver, and reproductive tissues. IRS4 is phosphorylated upon activation of insulin or insulin-like growth factor receptors, facilitating interactions with downstream signaling pathways, including PI3K and MAPK cascades. These pathways regulate diverse biological processes, such as energy metabolism, cell proliferation, and differentiation. IRS4 has garnered interest in the context of neurological development and metabolic regulation. Aberrant IRS4 expression or mutations have been linked to disorders like metabolic syndrome, infertility, and certain cancers. Understanding the unique role of IRS4 in signaling networks could provide insights into novel therapeutic strategies for metabolic and reproductive health challenges.
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