Insulin Receptor Substrate 1 (IRS-1) Antibody

Este producto es parte de IRS -Insulin receptor substrate
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52€ (10 µg)

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935106861
info@markelab.com
name
Insulin Receptor Substrate 1 (IRS-1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012860
tested applications
ELISA, WB, IHC, IF/ICC

Description

Rabbit polyclonal antibody against IRS-1 protein. Immunogen region is Internal.

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Product specifications

CategoryPrimary Antibodies
Immunogen TargetInsulin Receptor Substrate 1 (IRS-1)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionWB: 1/500 - 1/3000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/500, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 110 µg
Size 2100 µg
Size 3200 µg
Size 4300 µg
Size 51 mg
FormLiquid
Tested ApplicationsELISA, WB, IHC, IF/ICC
BufferPBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP35568
AliasIRS1, HIRS-1, insulin receptor substrate 1
BackgroundAntibody anti-IRS1
StatusRUO
NoteConcentration: 1 mg/ml -

IRS1 is a key adaptor protein that mediates insulin and insulin-like growth factor (IGF) signaling by interacting with the insulin receptor (IR) and IGF-1 receptor. Upon receptor activation, IRS1 is phosphorylated on tyrosine residues, recruiting downstream effectors such as PI3K and Grb2 to activate pathways like PI3K/Akt and Ras/MAPK. IRS1 regulates glucose uptake, metabolism, cell growth, and survival, playing a central role in insulin signaling. It is highly expressed in insulin-sensitive tissues like muscle, liver, and adipose. Dysregulation of IRS1 is associated with insulin resistance, obesity, type 2 diabetes, and cancer, where aberrant signaling promotes proliferation and survival. Knockout studies show growth retardation, metabolic abnormalities, and impaired glucose homeostasis, underscoring its importance in metabolism and cellular signaling.

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