Insulin Like Growth Factor Binding Protein 7 (IGFBP7) Antibody
383.5€ (100 µl)
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935106861
info@markelab.com
name
Insulin Like Growth Factor Binding Protein 7 (IGFBP7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx016094
tested applications
ELISA, IHC
Description
IGFBP7 Antibody is a Mouse Monoclonal against IGFBP7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Like Growth Factor Binding Protein 7 (IGFBP7) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16270 |
| Gene ID | 3490 |
| OMIM | 602867 |
| Alias | AGM,PSF,TAF,FSTL2,IBP-7,MAC25,IGFBP-7,RAMSVPS,IGFBP-7v,IGFBPRP1,IGF-binding protein 7 |
| Background | Antibody anti-IGFBP7 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
IGFBP7 is a member of the insulin-like growth factor binding protein family that regulates the availability and activity of insulin-like growth factors (IGFs) by binding to them with high affinity Unlike other IGFBPs, IGFBP7 also binds to insulin, modulating its signaling and promoting metabolic homeostasis IGFBP7 plays a critical role in regulating cell growth, apoptosis, and senescence and has anti-tumorigenic properties by inhibiting the mitogenic effects of IGFs Its expression is downregulated in cancers such as colorectal, breast, and prostate cancer where it acts as a tumor suppressor IGFBP7 also plays roles in cardiovascular health by influencing vascular smooth muscle cell proliferation and in fibrosis by mediating tissue remodeling and extracellular matrix deposition
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