Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody
325€ (0.1 mg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Insulin Like Growth Factor 2 Receptor (IGF2R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140404
tested applications
WB, FCM, IP
Description
CD222 Antibody is a Mouse Monoclonal against CD222.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Like Growth Factor 2 Receptor (IGF2R) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1-2 μg/ml, FCM: 2-6 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | A072 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified from cell culture supernatant by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P11717 |
| Gene ID | 3482 |
| Alias | Cation-independent mannose-6-phosphate receptor,MPR1,MPRI,CD222,CIMPR,M6P-R,MPR300,CI-M6PR,MPR 300,CI Man-6-P receptor,300 kDa mannose 6-phosphate receptor,IGF-II receptor |
| Background | Antibody anti-IGF2R |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The insulin-like growth factor 2 receptor (IGF2R) is a multi-functional transmembrane protein primarily known for binding and internalizing insulin-like growth factor 2 (IGF-2). Unlike the insulin-like growth factor 1 receptor (IGF1R), which signals to promote cell proliferation and survival, IGF2R generally acts to limit the bioavailability of IGF-2 and is therefore considered a negative regulator of growth. IGF2R also binds other ligands, including mannose-6-phosphate-tagged proteins, such as lysosomal enzymes, which it transports from the Golgi to lysosomes. This receptor is widely expressed in mammalian tissues and has important roles in development, cellular signaling, and protein trafficking. IGF2R is unique in its signaling capacity, as it lacks intrinsic tyrosine kinase activity. It operates mainly through ligand sequestration, ligand degradation, and the modulation of signaling pathways indirectly by reducing IGF-2 interactions with IGF1R. IGF2R’s role in growth regulation and its involvement in diseases, particularly cancer, has made it a focal point in biomedical research.
Related Products
Human IGF2R(Insulin Like Growth Factor 2 Receptor) ELISA Kit
Ver Producto
anti- IGF2R-Specific antibody
Ver Producto