Insulin Like Growth Factor 1 Receptor Phospho-Tyr1165/Phospho-Tyr1166 (IGF1R pY1165/pY1166) Antibody
429€ (100 µl)
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935106861
info@markelab.com
name
Insulin Like Growth Factor 1 Receptor Phospho-Tyr1165/Phospho-Tyr1166 (IGF1R pY1165/pY1166) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx333140
tested applications
ELISA, WB, IF/ICC
Description
IGF1R (pY1165/pY1166) Antibody is a Rabbit Polyclonal against IGF1R (pY1165/pY1166).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Like Growth Factor 1 Receptor Phospho-Tyr1165/Phospho-Tyr1166 (IGF1R pY1165/pY1166) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr1165/1166 |
| Recommended Dilution | WB: 1/500 - 1/1000, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08069 |
| Gene ID | 3480 |
| Alias | Insulin-like growth factor 1 receptor,IGFR,CD221,IGFIR,JTK13,IGF-I receptor |
| Background | Antibody anti-IGF1R |
| Status | RUO |
Descripción
The insulin-like growth factor 1 receptor (IGF1R) is a transmembrane receptor that plays a crucial role in cellular growth, survival, and metabolism. It is activated primarily by insulin-like growth factor 1 (IGF-1), a hormone structurally similar to insulin but with distinct biological functions. IGF1R is a member of the receptor tyrosine kinase (RTK) family, which includes receptors like the insulin receptor (INSR). IGF1R signaling is essential for normal development and is involved in many physiological processes, such as cell differentiation, proliferation, and apoptosis inhibition. This receptor is also significant in pathological states, especially cancer, where it can drive tumor growth and metastasis through enhanced cell survival and proliferation pathways.
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