Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody
338€ (60 µl)
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name
Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx000628
tested applications
WB
Description
Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody is a Rabbit Polyclonal antibody against Insulin Like Growth Factor 1 Receptor (IGF1R). Insulin Like Growth Factor 1 Receptor (IGF1R), also named as CD221, belongs to the protein kinase superfamily, Tyr protein kinase family and Insulin receptor subfamily. Insulin Like Growth Factor 1 Receptor (IGF1R) binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, Insulin Like Growth Factor 1 Receptor (IGF1R) binds IGF1. The hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, the hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Long and hybrid receptors composed of Insulin Like Growth Factor 1 Receptor (IGF1R) and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Defects in Insulin Like Growth Factor 1 Receptor (IGF1R) may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance). The antibody is specific to Insulin Like Growth Factor 1 Receptor (IGF1R).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Like Growth Factor 1 Receptor (IGF1R) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08069 |
| Gene ID | 3480 |
| NCBI Accession | NP_000866.1 |
| Alias | Insulin-like growth factor 1 receptor,IGFR,CD221,IGFIR,JTK13,IGF-I receptor |
| Background | Antibody anti-IGF1R |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The insulin-like growth factor 1 receptor (IGF1R) is a transmembrane receptor that plays a crucial role in cellular growth, survival, and metabolism. It is activated primarily by insulin-like growth factor 1 (IGF-1), a hormone structurally similar to insulin but with distinct biological functions. IGF1R is a member of the receptor tyrosine kinase (RTK) family, which includes receptors like the insulin receptor (INSR). IGF1R signaling is essential for normal development and is involved in many physiological processes, such as cell differentiation, proliferation, and apoptosis inhibition. This receptor is also significant in pathological states, especially cancer, where it can drive tumor growth and metastasis through enhanced cell survival and proliferation pathways.
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