Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

383.5€ (100 µl)
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935106861
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name
Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010963
tested applications
ELISA, IHC
Description
IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Insulin Like Growth Factor 1 Receptor (IGF1R) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | IgG2b |
Purification | Unpurified ascites. |
Size 1 | 100 µl |
Form | Liquid |
Tested Applications | ELISA, IHC |
Buffer | Ascitic fluid containing 0.03% sodium azide. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P08069 |
Gene ID | 3480 |
OMIM | 147370 |
Alias | Insulin-like growth factor 1 receptor,IGFR,CD221,IGFIR,JTK13,IGF-I receptor |
Background | Antibody anti-IGF1R |
Status | RUO |
Note | Concentration: Not determined. - |
Descripción
The insulin-like growth factor 1 receptor (IGF1R) is a transmembrane receptor that plays a crucial role in cellular growth, survival, and metabolism. It is activated primarily by insulin-like growth factor 1 (IGF-1), a hormone structurally similar to insulin but with distinct biological functions. IGF1R is a member of the receptor tyrosine kinase (RTK) family, which includes receptors like the insulin receptor (INSR). IGF1R signaling is essential for normal development and is involved in many physiological processes, such as cell differentiation, proliferation, and apoptosis inhibition. This receptor is also significant in pathological states, especially cancer, where it can drive tumor growth and metastasis through enhanced cell survival and proliferation pathways.
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