Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Cell ELISA Kit

Este producto es parte de MCL1 apoptosis regulator
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513.5€ (96 tests)

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935106861
info@markelab.com
name
Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595369
tested applications
ELISA

Description

MCL1 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Induced Myeloid Leukemia Cell Differentiation Protein (MCL1)
Reactivity
Human, Mouse, Rat
Detection Method
Colorimetric
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Tested Applications
ELISA
Availability
Shipped within 1-2 weeks. The validity for this kit is at least 6 months
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q07820
Gene ID
4170
OMIM
159552
Alias
BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S Mcl-1, M,bcl2-L-3,mcl1/EAT,Bcl-2-like protein 3,BCL2L3,Bcl-2-related protein EAT/mcl1
Background
Elisa kits for MCL1
Status
RUO
Note
Validity: 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Induced myeloid leukemia cell differentiation protein MCL1 is an anti-apoptotic protein that plays a critical role in regulating cell survival, particularly in hematopoietic and immune cells Mcl-1 belongs to the Bcl-2 family and helps prevent apoptosis by interacting with pro-apoptotic Bcl-2 family members, inhibiting their activity and preventing mitochondrial outer membrane permeabilization Mcl-1 is essential for the survival of various cell types, including myeloid cells, and its expression is tightly regulated during cell differentiation and immune responses Its dysregulation has been linked to cancer, particularly hematological malignancies, where overexpression of Mcl-1 promotes the survival of malignant cells and contributes to chemotherapy resistance In addition to its role in apoptosis, Mcl-1 is involved in regulating mitochondrial function, cell metabolism, and the stress response Mcl-1’s central role in both cell survival and apoptosis makes it a critical factor in normal cellular function and a potential target for therapeutic intervention in cancer and other diseases related to cell survival regulation

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