Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Antibody (Biotin)
169€ (20 µg)
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Name
Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx314397
Tested Applications
ELISA
Description
MCL1 Antibody (Biotin) is a Rabbit Polyclonal against MCL1 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Immunogen: Recombinant human Induced myeloid leukemia cell differentiation protein Mcl-1 protein (19-244AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q07820 |
| Gene ID | 4170 |
| NCBI Accession | NP_001184249.1, NM_001197320.1, NP_068779.1, NM_021960.4 |
| OMIM | 159552 |
| Alias | BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S Mcl-1, M,bcl2-L-3,mcl1/EAT,Bcl-2-like protein 3,BCL2L3,Bcl-2-related protein EAT/mcl1 |
| Background | Antibody anti-MCL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Induced myeloid leukemia cell differentiation protein MCL1 is an anti-apoptotic protein that plays a critical role in regulating cell survival, particularly in hematopoietic and immune cells Mcl-1 belongs to the Bcl-2 family and helps prevent apoptosis by interacting with pro-apoptotic Bcl-2 family members, inhibiting their activity and preventing mitochondrial outer membrane permeabilization Mcl-1 is essential for the survival of various cell types, including myeloid cells, and its expression is tightly regulated during cell differentiation and immune responses Its dysregulation has been linked to cancer, particularly hematological malignancies, where overexpression of Mcl-1 promotes the survival of malignant cells and contributes to chemotherapy resistance In addition to its role in apoptosis, Mcl-1 is involved in regulating mitochondrial function, cell metabolism, and the stress response Mcl-1’s central role in both cell survival and apoptosis makes it a critical factor in normal cellular function and a potential target for therapeutic intervention in cancer and other diseases related to cell survival regulation
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