Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Antibody

Este producto es parte de MCL1 apoptosis regulator
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169€ (20 µg)

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935106861
info@markelab.com
name
Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx109908
tested applications
ELISA

Description

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Antibody is a Rabbit Polyclonal antibody against Induced myeloid leukemia cell differentiation protein Mcl-1 homolog.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Induced Myeloid Leukemia Cell Differentiation Protein (MCL1)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P97287
Gene ID
17210
NCBI Accession
NP_032588.1, NM_008562.3
Alias
BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S Mcl-1, M,bcl2-L-3,mcl1/EAT,Bcl-2-like protein 3,BCL2L3,Bcl-2-related protein EAT/mcl1
Background
Antibody anti-MCL1
Status
RUO

Descripción

Induced myeloid leukemia cell differentiation protein MCL1 is an anti-apoptotic protein that plays a critical role in regulating cell survival, particularly in hematopoietic and immune cells Mcl-1 belongs to the Bcl-2 family and helps prevent apoptosis by interacting with pro-apoptotic Bcl-2 family members, inhibiting their activity and preventing mitochondrial outer membrane permeabilization Mcl-1 is essential for the survival of various cell types, including myeloid cells, and its expression is tightly regulated during cell differentiation and immune responses Its dysregulation has been linked to cancer, particularly hematological malignancies, where overexpression of Mcl-1 promotes the survival of malignant cells and contributes to chemotherapy resistance In addition to its role in apoptosis, Mcl-1 is involved in regulating mitochondrial function, cell metabolism, and the stress response Mcl-1’s central role in both cell survival and apoptosis makes it a critical factor in normal cellular function and a potential target for therapeutic intervention in cancer and other diseases related to cell survival regulation

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