Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Antibody
819€ (1 ml)
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Name
Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx173651
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S Mcl-1, M,bcl2-L-3,mcl1/EAT,Bcl-2-like protein 3,BCL2L3,Bcl-2-related protein EAT/mcl1 |
| Background | Antibody anti-MCL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Induced myeloid leukemia cell differentiation protein MCL1 is an anti-apoptotic protein that plays a critical role in regulating cell survival, particularly in hematopoietic and immune cells Mcl-1 belongs to the Bcl-2 family and helps prevent apoptosis by interacting with pro-apoptotic Bcl-2 family members, inhibiting their activity and preventing mitochondrial outer membrane permeabilization Mcl-1 is essential for the survival of various cell types, including myeloid cells, and its expression is tightly regulated during cell differentiation and immune responses Its dysregulation has been linked to cancer, particularly hematological malignancies, where overexpression of Mcl-1 promotes the survival of malignant cells and contributes to chemotherapy resistance In addition to its role in apoptosis, Mcl-1 is involved in regulating mitochondrial function, cell metabolism, and the stress response Mcl-1’s central role in both cell survival and apoptosis makes it a critical factor in normal cellular function and a potential target for therapeutic intervention in cancer and other diseases related to cell survival regulation
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