Inactive tyrosine-protein kinase 7 (PTK7) Antibody (Biotin)
260€ (50 µl)
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Name
Inactive tyrosine-protein kinase 7 (PTK7) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx344264
Tested Applications
ELISA
Description
Inactive tyrosine-protein kinase 7 (PTK7) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human PTK7.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Inactive tyrosine-protein kinase 7 (PTK7) Immunogen: Recombinant Human Inactive tyrosine-protein kinase 7 protein (772-1070 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13308 |
| Alias | CCK4,CCK-4,Colon carcinoma kinase 4,Protein-tyrosine kinase 7,Pseudo tyrosine kinase receptor 7,Tyrosine-protein kinase-like 7,Inactive tyrosine-protein kinase 7 |
| Background | Antibody anti-PTK7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Protein Tyrosine Kinase 7 (PTK7) is an inactive receptor tyrosine kinase that plays a critical role in cell signaling, development, and Wnt pathway regulation. Unlike other kinases, PTK7 lacks catalytic activity due to mutations in its kinase domain but functions as a co-receptor to regulate signaling pathways. Structurally, PTK7 has multiple extracellular immunoglobulin-like domains, a transmembrane region, and a pseudokinase domain. It is widely expressed during embryonic development and in adult tissues, particularly in processes involving cell polarity, migration, and morphogenesis. PTK7 is crucial for Wnt signaling, especially the non-canonical planar cell polarity (PCP) pathway, where it regulates tissue organization and cell orientation. It also modulates processes such as angiogenesis, neural development, and epithelial cell migration. PTK7 has been implicated in cancer progression, including colorectal cancer, gastric cancer, and leukemia, where it promotes metastasis, angiogenesis, and resistance to apoptosis. Altered PTK7 expression is associated with poor prognosis in cancer patients. Given its importance in development and disease, PTK7 is being explored as a therapeutic target in oncology and regenerative medicine.
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