Immunoglobulin Superfamily Member 5 (IGSF5) Antibody
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Description
Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Immunoglobulin Superfamily Member 5 (IGSF5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NSI5 |
| Alias | GSF5,JAM4,Junctional adhesion molecule 4 |
| Background | Antibody anti-IGSF5 |
| Status | RUO |
Descripción
IGSF5, also known as Junctional Adhesion Molecule-Like (JAML), is a transmembrane protein involved in immune responses and epithelial integrity. It contains immunoglobulin (Ig)-like domains that mediate interactions with other adhesion molecules and receptors. IGSF5 is expressed in epithelial cells and immune cells, such as γδ T cells, where it facilitates cell adhesion and immune surveillance. Functionally, IGSF5 contributes to tissue repair, immune cell activation, and barrier integrity. Dysregulation of IGSF5 is linked to inflammatory diseases and tissue damage, particularly in the gut and skin.
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