IFN-Gamma (IFNG) Antibody (PE)
429€ (100 tests)
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935106861
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name
IFN-Gamma (IFNG) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx139548
tested applications
FCM
Description
IFN-gamma Antibody is a Mouse Monoclonal against IFN-gamma.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | IFN-Gamma (IFNG) |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Validated in IHC-P and ICC. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 Kappa |
| Clone ID | M720 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P01579 |
| Gene ID | 3458 |
| Alias | IFG,IFI,IMD69,IFN-gamma,Immune interferon |
| Background | Antibody anti-IFNG |
| Status | RUO |
Descripción
Interferon Gamma (IFNG) is a pivotal cytokine of the immune system, classified as a type II interferon, and is primarily produced by activated T lymphocytes, natural killer (NK) cells, and NKT cells. Unlike type I interferons, IFNG signals through a distinct receptor, the interferon gamma receptor (IFNGR), leading to the activation of the JAK-STAT pathway and the induction of a unique set of genes critical for immune defense. IFNG plays a central role in coordinating both innate and adaptive immune responses, including macrophage activation for enhanced phagocytosis and antigen processing, upregulation of MHC class I and II molecules to improve antigen presentation, and stimulation of cytotoxic T cells. It is also essential in granuloma formation to contain intracellular pathogens, such as Mycobacterium tuberculosis. Dysregulation of IFNG activity is implicated in various inflammatory and autoimmune conditions, as well as chronic infections. Its therapeutic potential in immunotherapy and as a biomarker in certain cancers and infectious diseases remains an active focus of study.
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