Human Urotensin-2 receptor (UTS2R) ELISA Kit
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Description
Human Urotensin-2 receptor (UTS2R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Urotensin-2 receptor (UTS2R) concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Urotensin-2 receptor (UTS2R) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UKP6 |
| Alias | UTS2R,GPR14,UII-R1,UTR2,G protein-coupled receptor 14,urotensin II receptor,SENR,UR-2-R,UTR |
| Background | Elisa kits for UTS2R |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
UTS2R is a G protein-coupled receptor activated by urotensin 2 (U-2), a potent vasoconstrictor peptide involved in regulating cardiovascular function, particularly blood pressure and vascular tone. UTS2R couples to Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, leading to vasoconstriction and modulation of smooth muscle contraction. Urotensin 2 is a critical mediator in the regulation of blood vessel function, and UTS2R’s expression in the vasculature suggests that it plays an important role in blood pressure homeostasis and vascular remodeling. Dysregulation of UTS2R signaling is associated with cardiovascular diseases such as hypertension and heart failure. Antagonists of UTS2R are being explored for their therapeutic potential in treating conditions related to excessive vasoconstriction, including pulmonary arterial hypertension and atherosclerosis.
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