Human UBX domain-containing protein 8 (UBXN8) ELISA Kit

Este producto es parte de UBXN - UBX domain protein
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715€ (96 tests)

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935106861
info@markelab.com
name
Human UBX domain-containing protein 8 (UBXN8) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx552439
tested applications
ELISA

Description

Human UBX domain-containing protein 8 (UBXN8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human UBX domain-containing protein 8 (UBXN8) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
UBX domain-containing protein 8 (UBXN8)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O00124
Gene ID
7993
OMIM
602155
Alias
D8S2298E,REP8,UBXD6,Reproduction 8 protein,UBX domain-containing protein 6
Background
Elisa kits for UBXN8
Status
RUO
Note
Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

UBX domain protein 8 (UBXN8) is a member of the UBX domain-containing protein family that functions as a critical cofactor of p97/VCP, an ATPase involved in protein degradation and cellular quality control UBXN8 plays a role in the extraction and degradation of ubiquitinated proteins, particularly through endoplasmic reticulum-associated degradation (ERAD) and proteasomal pathways It participates in maintaining proteostasis under stress conditions by linking p97 to the ubiquitin-proteasome system and autophagy pathways UBXN8 also regulates mitochondrial homeostasis, ensuring the turnover of damaged proteins and contributing to cellular energy metabolism Dysregulation of UBXN8 has been associated with neurodegenerative diseases such as Parkinson’s, where protein clearance pathways are impaired, leading to toxic protein aggregates Emerging studies suggest that UBXN8 also influences DNA repair processes and cellular responses to oxidative stress In cancer biology, altered UBXN8 expression has been linked to tumor progression and resistance to therapy through its role in protein turnover and apoptosis regulation Its critical functions in proteostasis, mitochondrial health, and cellular stress responses underscore its importance in maintaining cellular homeostasis

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