Human UBX Domain-Containing Protein 7 (UBXN7) ELISA Kit

Background

UBX domain protein 7 (UBXN7) is a multifunctional UBX-containing protein that interacts with p97/VCP to regulate protein degradation, ubiquitin-proteasome pathways, and cellular stress responses UBXN7 serves as an adaptor protein, linking p97 to ubiquitin ligases and deubiquitinases to facilitate the extraction and turnover of ubiquitinated proteins It plays a key role in endoplasmic reticulum-associated degradation (ERAD), ensuring the removal of misfolded or damaged proteins from the ER membrane UBXN7 is also involved in the regulation of DNA damage repair, where it coordinates p97 activity to remove ubiquitinated repair proteins, thereby maintaining genome stability Dysregulation of UBXN7 has been implicated in cancer, where its role in protein turnover and DNA repair supports tumor growth and survival UBXN7 is further linked to neurodegenerative diseases, where impaired p97 activity and protein clearance result in toxic protein aggregates Its ability to regulate protein homeostasis and genome stability highlights UBXN7’s critical function in cellular quality control and stress management pathways