Human Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) Protein
234€ (10 µg)
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name
Human Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069591
tested applications
WB, SDS-PAGE
Description
Recombinant Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L5 (UCHL5) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 37.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr2-Lys316 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y5K5 |
| Alias | UCH37,CGI-70,INO80R,UCH-L5,Ubiquitin carboxyl-terminal hydrolase isozyme L5,Ubiquitin thioesterase L5 |
| Background | Protein UCHL5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
UCHL5, also known as UCH37, is a deubiquitinating enzyme (DUB) that plays a key role in the ubiquitin-proteasome system by removing ubiquitin chains from proteasomal substrates, thereby regulating protein turnover and degradation. UCHL5 interacts with the 19S regulatory particle of the 26S proteasome, facilitating the recycling of ubiquitin to maintain cellular proteostasis. It is involved in DNA repair, cell cycle progression, and stress responses, making it crucial for cellular homeostasis. UCHL5 has also been implicated in tumorigenesis, where its overexpression promotes cell survival, proliferation, and chemoresistance by preventing the degradation of oncogenic proteins. Inhibitors of UCHL5 have shown potential as anti-cancer agents by enhancing proteasomal degradation of key regulatory proteins. Knockdown studies reveal its role in impaired cell growth, defective DNA repair, and increased apoptosis, highlighting UCHL5's importance in protein homeostasis, cellular stability, and cancer progression.
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