Human Inactive Tyrosine-Protein Kinase 7 (PTK7) Protein
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Description
Human PTK7 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Inactive Tyrosine-Protein Kinase 7 (PTK7) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 25.8 kDa Observed MW (SDS-PAGE): 26 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu853-Pro1070 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13308 |
| Gene ID | 5754 |
| OMIM | 601890 |
| Alias | CCK4,CCK-4,Colon carcinoma kinase 4,Protein-tyrosine kinase 7,Pseudo tyrosine kinase receptor 7,Tyrosine-protein kinase-like 7,Inactive tyrosine-protein kinase 7 |
| Background | Protein PTK7 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Protein Tyrosine Kinase 7 (PTK7) is an inactive receptor tyrosine kinase that plays a critical role in cell signaling, development, and Wnt pathway regulation. Unlike other kinases, PTK7 lacks catalytic activity due to mutations in its kinase domain but functions as a co-receptor to regulate signaling pathways. Structurally, PTK7 has multiple extracellular immunoglobulin-like domains, a transmembrane region, and a pseudokinase domain. It is widely expressed during embryonic development and in adult tissues, particularly in processes involving cell polarity, migration, and morphogenesis. PTK7 is crucial for Wnt signaling, especially the non-canonical planar cell polarity (PCP) pathway, where it regulates tissue organization and cell orientation. It also modulates processes such as angiogenesis, neural development, and epithelial cell migration. PTK7 has been implicated in cancer progression, including colorectal cancer, gastric cancer, and leukemia, where it promotes metastasis, angiogenesis, and resistance to apoptosis. Altered PTK7 expression is associated with poor prognosis in cancer patients. Given its importance in development and disease, PTK7 is being explored as a therapeutic target in oncology and regenerative medicine.
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