Human Tumor Necrosis Factor Receptor Superfamily Member 4 / CD134 (TNFRSF4) Protein
247€ (20 µg)
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name
Human Tumor Necrosis Factor Receptor Superfamily Member 4 / CD134 (TNFRSF4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691762
tested applications
SDS-PAGE
Description
Human OX40 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Ala 216) of human TNFRSF4 (NP_003318.1) was expressed, fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | OX40 |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 21.7 kDa Sequence Fragment: Met1-Ala216 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_003318.1 |
| Alias | OX40,ACT35,CD134,IMD16,TXGP1L,OX40L receptor,TAX transcriptionally-activated glycoprotein 1 receptor |
| Background | Protein TNFRSF4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNFRSF4, commonly known as OX40 (CD134), is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is an important costimulatory molecule expressed on T cells, specifically induced upon T cell activation. TNFRSF4 is known for its involvement in regulating immune responses, especially in T-cell proliferation, survival, and memory formation. As an immune-regulatory receptor, it primarily interacts with its ligand, OX40L (TNFSF4), which is expressed on antigen-presenting cells (APCs), such as dendritic cells, B cells, and macrophages. OX40’s role in immune modulation is significant because it amplifies T-cell responses during both acute infections and in chronic immune responses, such as autoimmune diseases and cancer. By sustaining T-cell activation and enhancing immune memory, OX40 has become a central target in immunotherapy research, especially in the contexts of cancer immunotherapy and autoimmune diseases. Its ability to promote prolonged immune responses also makes it a critical regulator in various immune-related diseases, where modulation of OX40-OX40L interactions can potentially benefit patient outcomes.
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